Osteopenia

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What is osteopenia?

Osteopenia is a bone condition characterized by a decreased density of bone, which leads to bone weakening and an increased risk of breaking a bone (fracture). Osteopenia and osteoporosis are related conditions. In osteopenia, however, the bone loss is not as severe as in osteoporosis. That means someone with osteopenia is more likely to fracture a bone than someone with a normal bone density but is less likely to fracture a bone than someone with osteoporosis.

Osteomalacia, osteomyelitis, and osteoarthritis are different conditions that are frequently confused with osteopenia because they sound similar. Osteomalacia is a disorder of the mineralization of newly formed bone, which causes the bone to be weak and more prone to fracture. There are many causes of osteomalacia, including vitamin D deficiency and low blood phosphate levels. Osteomyelitis is bone infection. Osteoarthritis is joint inflammation featuring cartilage loss and is the most common type of arthritis. Osteoarthritis does not cause osteopenia, osteoporosis, or a decreased bone mineral density.

What causes osteopenia?

Osteopenia has multiple causes. Common causes include

  • genetics (familial predisposition to osteopenia or osteoporosis, as well as other genetic disorders);


  • hormonal causes, including decreased estrogen (such as in women after menopause) or testosterone;


  • smoking;


  • excess alcohol;


  • thin frame;


  • immobility;


  • certain medications (such as corticosteroids, including prednisone) and antiseizure medications;


  • malabsorption due to conditions (such as celiac sprue);


  • and chronic inflammation due to medical conditions (such as rheumatoid arthritis).


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