oseltamivir, Tamiflu (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DOSING: Oseltamivir is administered orally. For the best results, treatment should begin within 2 days of symptom onset or exposure.

  • The recommended dose for treating adults with flu is 75 mg twice daily for five days.
  • Children are treated with 30-75 mg twice daily for five days. Dosing depends on body weight.
  • The adult dose for prevention of flu is 75 mg daily for 10 days. Children receive 30-75 mg once daily for 10 days.

DRUG INTERACTIONS: Oseltamivir potentially may interfere with the action of the live attenuated flu vaccine that is given by injection because oseltamivir prevents viral replication. Therefore, live attenuated flu vaccine should not be administered within two weeks before or 48 hours after administration of oseltamivir.

PREGNANCY: The Centers for Disease Control (CDC) recommends use of oseltamivir for treating flu in pregnant women.

NURSING MOTHERS: The CDC recommends that women with flu who have recently given birth may be treated with oseltamivir. Oseltamivir is approved for use in children one year old and older, and available evidence suggests that the risk of adverse events is low when oseltamivir is used in children less than 1 year old.

SIDE EFFECTS: The most frequent side effects of oseltamivir are nausea, vomiting, diarrhea, bronchitis, abdominal pain, headache and dizziness. Administering oseltamivir after meals helps reduce nausea. Other reported adverse events include allergic reactions, skin reactions, seizures, behavioral disturbances, and aggravation of diabetes.

REFERENCES:

Tamiflu Prescribing Information, 2008. Roche Laboratories.

CDC. "Updated Interim Recommendations for the Use of Antiviral Medications in the Treatment and Prevention of Influenza for the 2009-2010 Season."

WebMD.com. FDA Approves Tamiflu for Infants.


Medically Reviewed by a Doctor on 1/10/2013


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