oseltamivir, Tamiflu (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Oseltamivir  is not approved to prevent the flu in this age group.

Oseltamivir also is used for preventing the flu in healthy individuals 1 year and older, but it is not a substitute for flu vaccine.

It also is used off-label for prevention and treatment of H1N1 (swine flu). During the H1N1 outbreak of 2009, the FDA approved emergency use of oseltamivir for children less than 1 year old.

SIDE EFFECTS: The most frequent side effects of oseltamivir are:

Administering oseltamivir after meals helps reduce nausea.

Other reported adverse events include:

  • Allergic reactions
  • Skin reactions
  • Seizures
  • Behavioral disturbances
  • Aggravation of diabetes



PREPARATIONS: Capsules: 30, 45, and 75 mg. Suspension: 6 mg/ml and 12 mg/ml

STORAGE: Oseltamivir should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

DOSING: Oseltamivir is administered orally. For the best results, treatment should begin within 2 days of symptom onset or exposure.

  • The recommended dose for treating adults with flu is 75 mg twice daily for five days.
  • Children are treated with 30-75 mg twice daily for five days. Dosing depends on body weight.
  • The adult dose for prevention of flu is 75 mg daily for 10 days. Children receive 30-75 mg once daily for 10 days.

DRUG INTERACTIONS: Oseltamivir potentially may interfere with the action of the live attenuated flu vaccine that is given by injection because oseltamivir prevents viral replication. Therefore, live attenuated flu vaccine should not be administered within two weeks before or 48 hours after administration of oseltamivir.

Medically Reviewed by a Doctor on 12/29/2014

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