orphenadrine (Norflex) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Rare but serious side effects include aplastic anemia and life threatening allergic reactions.
GENERIC AVAILABLE: Yes
STORAGE: Tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
DOSING: The recommended dose is one 100 mg tablet by mouth twice daily in the morning and evening.
Orphenadrine may cause drowsiness. Taking orphenadrine with other drugs that have similar CNS depressant effects may increase the CNS depressant effects of orphenadrine.
Orphenadrine may cause anticholingeric side effects such as:
Taking medications that also have anticholingeric effects increases the anticholinergic effect of orphenadrine.
PREGNANCY: Orphenadrine has not been adequately evaluated in pregnant females and is classified as pregnancy risk category C (adverse effects in animals but inadequate data in humans). Due to the lack of conclusive safety data, orphenadrine should be avoided in pregnancy if possible.
NURSING MOTHERS: It is not known whether orphenadrine is secreted into breast milk. Orphenadrine should be avoided in pregnancy if possible.
REFERENCE: FDA Prescribing Information.
Medically Reviewed by a Doctor on 6/9/2015
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