orphenadrine (Norflex)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is orphenadrine-oral, and how does it work (mechanism of action)?

Orphenadrine is an oral central acting skeletal muscle relaxant that is used for the treatment of acute muscle aches, pain, or spasms. The exact mechanism of action in relieving muscuar aches or spasms is not completely understood. Orphenadrine may reduce muscle spasms through actions on motor centers or the medulla in the brain. Orphenadrine does not seem to have any direct relaxant effects on skeletal muscle.

Orphenadrine is structurally related to the antihistamine diphenhydramine (Benadryl), however, its antihistamine activity is less than that of diphenhydramine. Orphenadrine also has some local anesthetic effects. The FDA approved Orphenadrine in 1959.

What brand names are available for orphenadrine-oral?

Norflex (Discontinued in the US)

Is orphenadrine-oral available as a generic drug?


Do I need a prescription for orphenadrine-oral?


What are the side effects of orphenadrine-oral?

Side effects of orphenadrine include:

Rare but serious side effects include aplastic anemia and life threatening allergic reactions.

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