GENERIC NAME: ondansetron
BRAND NAME: Zofran, Zofran ODT, Zuplenz
DRUG CLASS AND MECHANISM: Ondansetron is an anti-nausea medication most often used to prevent nausea and vomiting caused by chemotherapy. Chemotherapy agents increase secretion of serotonin which stimulates serotonin (5-HT3) receptors in the brain, causing nausea and vomiting. Ondansetron works by selectively blocking serotonin (5-HT3) receptors, reducing the effect of increased serotonin due to chemotherapy. The FDA approved ondansetron in December 1992.
PRESCRIBED FOR: Ondansetron is used to prevent nausea and vomiting due to chemotherapy, radiation, and surgery.
SIDE EFFECTS: Side effects of ondansetron are
Some individuals may develop abnormal heart rate and rhythm.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets (ODT): 4, 8 mg; Oral Film: 4, 8 mg; Tablet: 4, 8, 24 mg; Solution: 4 mg/5 ml. Injectable; 2 mg/ml
STORAGE: Store ondansetron between 2 C and 30 C (36 and 86 F).
Dosing for adults
- Highly nauseating chemotherapy: 24 mg orally dissolved on tongue 30 minute prior to start of a single-day chemotherapy.
- Moderately nauseating chemotherapy: Take 8 mg tablet 30 minute prior to chemotherapy and repeated in 8 hours, then 8 mg every 12 hours for 1 to 2 days after chemotherapy.
- Radiation-induced nausea and vomiting: Take 8 mg orally 1 to 2 hours prior to radiation and every 8 hours after first dose, as needed.
- Post-surgery nausea and vomiting: 16 mg orally 1 hour before anesthesia.
Dosing for children
- Moderately nauseating chemotherapy (12 years and older) : 8 mg orally prior to chemotherapy and repeated in 8 hours, then 8 mg every 12 hours for 1 to 2 days after chemotherapy.
- Moderately nauseating chemotherapy (4 to 11 years): 4 mg orally 30 minute prior to chemotherapy and repeated in 4 and 8 hours after the first dose, then every 8 hours for 1 to 2 days after chemotherapy.
- Not recommended for children under 4 years old.
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