ondansetron (Zofran, Zofran ODT, Zuplenz)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is ondansetron oral disintegrating tablet, and how does it work (mechanism of action)?

Ondansetron is an anti-nausea medication most often used to prevent nausea and vomiting caused by chemotherapy. Chemotherapy agents increase secretion of serotonin which stimulates serotonin (5-HT3) receptors in the brain, causing nausea and vomiting. Ondansetron works by selectively blocking serotonin (5-HT3) receptors, reducing the effect of increased serotonin due to chemotherapy. The FDA approved ondansetron in December 1992.

What brand names are available for ondansetron oral disintegrating tablet?

Zofran, Zofran ODT, Zuplenz

Is ondansetron oral disintegrating tablet available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for ondansetron oral disintegrating tablet?

Yes

What are the side effects of ondansetron oral disintegrating tablet?

Side effects of ondansetron are

Some individuals may develop abnormal heart rate and rhythm.

Medically Reviewed by a Doctor on 7/21/2015

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