Ondansetron, orally disintegrating tablet (Zofran ODT)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: Ondansetron, orally disintegrating tablet
BRAND NAME: Zofran ODT
DRUG CLASS AND MECHANISM: Ondansetron is an oral medication used for treating nausea that is most often used to prevent nausea and vomiting caused by cancer chemotherapy. Chemotherapeutic agents increase secretion of serotonin which stimulates serotonin (5-HT3) receptors in the brain, causing nausea and vomiting. Ondansetron works by blocking serotonin (5-HT3) receptors, reducing the effect of increased serotonin. The FDA approved ondansetron orally disintegrating tablets in January 1999.
GENERIC AVAILABLE: Yes
PREPARATIONS: Orally disintegrating tablets are available in 4 and 8 mg in unit dose packs.
STORAGE: Ondansetron should be stored between 2 C and 30 C (36 F and 86 F).
PRESCRIBED FOR: Ondansetron is used to prevent nausea and vomiting due to chemotherapy, radiation, and post-surgery.
DRUG INTERACTIONS: Ondansetron and apomorphine should not be used together due to the possibility of sudden lowering of blood pressure and loss of consciousness.
Dronedarone (Multaq)can increase blood levels of ondansetron by reducing its breakdown in the liver. This may increase side effects of ondansetron. This combination may also increase the risk of abnormal heart beats.
PREGNANCY: There are no adequate studies done on ondansetron to determine its safe and effective use in rel="dt" onclick="wmdTrack('embd-lnk');"pregnant women.
NURSING MOTHERS: It is not known whether ondansetron enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.
Last Editorial Review: 4/23/2014
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