ondansetron (Zofran, Zofran ODT, Zuplenz)

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GENERIC NAME: ondansetron

BRAND NAME: Zofran, Zofran ODT, Zuplenz

DRUG CLASS AND MECHANISM: Ondansetron is an anti-nausea medication most often used to prevent nausea and vomiting caused by chemotherapy. Chemotherapy agents increase secretion of serotonin which stimulates serotonin (5-HT3) receptors in the brain, causing nausea and vomiting. Ondansetron works by selectively blocking serotonin (5-HT3) receptors, reducing the effect of increased serotonin due to chemotherapy. The FDA approved ondansetron in December 1992.

PRESCRIBED FOR: Ondansetron is used to prevent nausea and vomiting due to chemotherapy, radiation, and surgery.

Medically Reviewed by a Doctor on 7/21/2015

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