omega-3-acid ethyl esters (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

The precise way in which Lovaza works is not clear; however, its proposed mechanism of action is by decreasing the amount of TG produced by the liver and increasing the removal of TG by the liver. Other drugs that reduce TG levels include fibric acids such as gemfibrozil (Lopid), nicotinic acids such as niacin (Nicobid, Nicolar, Slo-Niacin), and statins such as atorvastatin (Lipitor). Lovaza was FDA approved on November 10, 2004.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Capsules: 1 gm

STORAGE: Lovaza should be stored at 25 C (77 F) and not frozen.

PRESCRIBED FOR: Lovaza is indicated as an adjunct to diet to reduce TG levels in adult patients with severe elevations of TG (≥ 500 mg/dL). Off-label uses of Lovaza include prevention of atherosclerosis and prevention of angina, heart attacks, and strokes. It is also used as a dietary supplement.

DOSING: The daily dose of Lovaza for reducing triglycerides is 4 grams per day. The daily dose may be taken as a single 4 gram dose (four capsules) or as two, 2 gram doses (two capsules given twice daily). Patients should be advised to swallow Lovaza capsules whole. They should not break open, crush, dissolve, or chew Lovaza capsules.

The dose of Lovaza as a dietary supplement is 1 to 2 capsules every 8 hours with meals.

DRUG INTERACTIONS: Taking Lovaza with an anticoagulant (blood thinner) affecting coagulation such as aspirin, nonsteroidal antiinflammatory drugs (NSAIDS) such as ibuprofen (Motrin), warfarin (Coumadin), and heparin (Hep-Lock U/P) should be monitored periodically as Lovaza may increase the risk of bleeding.

Since some drugs may increase TG levels, patients should tell their doctor or pharmacist of the following medications before using Lovaza since their doctor may want to change the doses of these medications or monitor their effects; beta-blockers such as atenolol (Tenormin), diuretics or water pills such as hydrochlorothiazide (Diuril), and vitamins/supplements (fish/flaxseed/cod liver oils).

Medically Reviewed by a Doctor on 10/28/2014


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