olsalazine, Dipentum (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Other important side effects include:

Gastrointestinal disturbances commonly occur in persons who take olsalazine. Diarrhea occurs in about 1 of every 6 persons who take it; about one in 20 need to discontinue therapy because the diarrhea is severe. Abdominal pain or cramps occur in 1 in 10 persons, and nausea or vomiting occurs in 1 in 20. Other side effects, including dizziness, depression, and headache, occur less frequently than gastrointestinal effects during therapy. Rashes occur in 2.3% of persons and joint pain in 4%.



PREPARATIONS: Capsules: 250 mg.

STORAGE: The capsules should be kept at room temperature, 15 C to 30 C (59 F to 86 F).

DOSING: Olsalazine usually is administered at a dose of 500 mg (two capsules) twice daily. It should be taken with meals.

DRUG INTERACTIONS: Administering salicylic acid derivatives with low molecular weight heparins (for example, enoxaparin) used as blood thinners may increase the risk of bleeding after neuraxial anesthesia (local anesthesia with anesthetics that are injected around nerves). Olsalazine may increase the effect of warfarin (Coumadin), a blood thinner, and cause bleeding. Administering olsalazine with 6-mercaptopurine or thioguanine may increase the risk of bone marrow suppression, resulting in decreased blood cells.

PREGNANCY: It is not known whether olsalazine crosses the placenta to the fetus.

NURSING MOTHERS: Mesalamine, which is the active form of olsalazine, may be secreted into breast milk and cause diarrhea in the infant.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 7/23/2015

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