olsalazine, Dipentum

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PRESCRIPTION: yes

GENERIC AVAILABLE: no

PREPARATIONS: Capsules: 250 mg.

STORAGE: The capsules should be kept at room temperature, 15 C to 30 C (59 F to 86 F).

DOSING: Olsalazine usually is administered at a dose of 500 mg (two capsules) twice daily. It should be taken with meals.

DRUG INTERACTIONS: Administering salicylic acid derivatives with low molecular weight heparins (for example, enoxaparin) used as blood thinners may increase the risk of bleeding after neuraxial anesthesia (local anesthesia with anesthetics that are injected around nerves). Olsalazine may increase the effect of warfarin (Coumadin), a blood thinner, and cause bleeding. Administering olsalazine with 6-mercaptopurine or thioguanine may increase the risk of bone marrow suppression, resulting in decreased blood cells.

PREGNANCY: It is not known whether olsalazine crosses the placenta to the fetus.

NURSING MOTHERS: Mesalamine, which is the active form of olsalazine, may be secreted into breast milk and cause diarrhea in the infant.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 7/23/2015

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