GENERIC NAME: olsalazine

BRAND NAME: Dipentum

DRUG CLASS AND MECHANISM: Olsalazine is a derivative of salicylic acid. Inactive by itself, it is converted by the bacteria in the colon to mesalamine. Mesalamine works as an anti-inflammatory agent in treating inflammatory diseases of the intestines. Its benefit is believed to be due to a local effect from within the bowel and, therefore, following oral administration very little (less than 10%) is absorbed. Mesalamine is thought to be the active component of sulfasalazine (Azulfidine). Olsalazine was approved by the FDA in July, 1990.

PRESCRIPTION: yes

GENERIC AVAILABLE: no

PREPARATIONS: Capsules (beige-orange) containing 250mg.

STORAGE: The capsules should be kept at room temperature, 15-30°C (59-86°F).

PRESCRIBED FOR: Olsalazine is used for the treatment of mild to moderately severe ulcerative colitis.

DOSING: Olsalazine is usually administered at a dose of 500mg (two capsules) twice daily. It is taken with meals.

DRUG INTERACTIONS: There are no known drug interactions with olsalazine.

PREGNANCY: It is not known whether olsalazine crosses the placenta to the fetus.

NURSING MOTHERS: It is not known whether olsalazine is secreted into breast milk.

SIDE EFFECTS: Gastrointestinal disturbances commonly occur in persons who take olsalazine. Diarrhea occurs in about 1 of every 6 persons who take it; about one in 20 need to discontinue therapy because the diarrhea is severe. Abdominal pain or cramps occur in 1 in 10 persons, and nausea or vomiting occurs in 1 in 20. Other side effects, including dizziness, depression, and headache, occur less frequently than gastrointestinal effects during therapy. Rashes occurs in 2.3% of persons and joint pain in 4%.

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Last Editorial Review: 12/31/1997