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OLANZAPINE/FLUOXETINE-ORAL (cont.)

DRUG INTERACTIONS: Certain medications taken with this product could result in serious, even fatal, drug interactions. Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks of starting this medication, or at least 5 weeks after stopping it. Also avoid taking thioridazine with this product or within 5 weeks after stopping treatment with olanzapine/fluoxetine. Consult your doctor or pharmacist for more information. This drug should not be used with the following medications because very serious (possibly fatal) interactions may occur: astemizole, terfenadine, weight loss drugs (e.g., sibutramine, phentermine). Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anti-anxiety medicines (e.g., diazepam), antiarrhythmics (e.g., flecainide, propafenone), other antidepressants (e.g., nefazodone, trazodone, venlafaxine), certain anti-seizure drugs (e.g., carbamazepine, phenytoin), aripiprazole, atomoxetine, clozapine, other drugs which can cause bleeding/bruising (e.g., thrombolytic drugs such as TPA, anticoagulants such as heparin or warfarin, antiplatelet drugs including NSAIDs such as ibuprofen), haloperidol, herbal/natural products (e.g., St John's wort, ayahuasca), drugs used for high blood pressure, lithium, medicines for Parkinson's disease, tramadol, tricyclic antidepressants (e.g., amitriptyline), "triptan" migraine drugs (e.g., sumatriptan, zolmitriptan), tryptophan, vinblastine. Low-dose aspirin (usually 81-325 mg per day) for heart attack or stroke prevention should be continued unless your doctor instructs you otherwise. Aspirin is similar to NSAID drugs, and can increase the risk of bleeding in combination with this medication (see above). Discuss the risks and benefits with your doctor. Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: antihistamines that cause drowsiness (e.g., diphenhydramine), medicine for sleep (e.g., sedatives), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine), tranquilizers. Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products. Cigarette smoking decreases blood levels of this medication (hepatic enzyme induction). Tell your doctor if you smoke or if you have recently stopped smoking. Do not start or stop any medicine without doctor or pharmacist approval.




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