olanzapine, Zyprexa, Zydis, Zyprexa Relprevv

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Coping With Schizophrenia

Patients may develop severe sedation, coma, and or delirium after an injection of extended release olanzapine. Patients must be examined for 3 hours after receiving an injection.

Elderly patients with dementia related psychosis treated with antipsychotics are at an increased risk of death.

Olanzapine may increase prolactin levels. Increased prolactin levels may manifest as abnormal menstruation, sexual dysfunction, and breast enlargement.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 2.5, 5, 7.5, 10, 15, 20 mg. Tablets (orally disintegrating): 5, 10, 15, 20 mg. Injection (immediate release): 10 mg vial. Suspension for Injection (extended release): 210, 300, and 405 mg (powder).

STORAGE: Tablets should be kept at room temperature, 20 C - 25 C (68 F - 77 F). Suspension is stored at room temperature not to exceed 30 C (86 F).

DOSING: The usual oral dose of olanzapine for treating schizophrenia is 10-20 mg once daily. Therapy is initiated with 5-10 mg/day, and the dose may be increased by 5 mg a day at weekly intervals. The maximum dose is 20 mg daily. The recommended dose of extended release injection is 150-405 mg every 2 or 4 weeks.

Treatment of bipolar disorder usually is initiated with oral doses of 10-15 mg once daily. The dose may be increased by 5 mg daily at 24 hour intervals. The maximum dose is 20 mg daily.

The usual dose for treating agitation due to schizophrenia or bipolar disorder is 10 mg administered by intramuscular injection (immediate release). Additional 10 mg doses may be administered, but the efficacy of total doses greater than 30 mg daily have not been adequately evaluated.

The recommended treatment for resistant depression is 5-20 mg of olanzapine combined with 20-50 mg of fluoxetine once daily in the evening while the recommended treatment for depression associated with bipolar disorder is 5-12.5 mg olanzapine combined with 20-50 mg fluoxetine once daily in the evening.

DRUG INTERACTIONS: Carbamazepine (Tegretol) can reduce blood concentrations of olanzapine, possibly necessitating higher doses of olanzapine. Other drugs that may also reduce blood levels of olanzapine are omeprazole (Prilosec) and rifampin.

Medically Reviewed by a Doctor on 1/12/2015

Quick GuideSchizophrenia Pictures Slideshow: Types, Causes, Symptoms, and Treatment

Schizophrenia Pictures Slideshow: Types, Causes, Symptoms, and Treatment
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