- Schizophrenia Slideshow Pictures
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- Physical Symptoms of Depression Slideshow
- What is olanzapine, and how does it work (mechanism of action)?
- What brand names are available for olanzapine?
- Is olanzapine available as a generic drug?
- Do I need a prescription for olanzapine?
- What are the side effects of olanzapine?
- What is the dosage for olanzapine?
- Which drugs or supplements interact with olanzapine?
- Is olanzapine safe to take if I'm pregnant or breastfeeding?
- What else should I know about olanzapine?
What is the dosage for olanzapine?
The usual oral dose of olanzapine for treating schizophrenia is 10-20 mg once daily. Therapy is initiated with 5-10 mg/day, and the dose may be increased by 5 mg a day at weekly intervals. The maximum dose is 20 mg daily. The recommended dose of extended release injection is 150-405 mg every 2 or 4 weeks.
Treatment of bipolar disorder usually is initiated with oral doses of 10-15 mg once daily. The dose may be increased by 5 mg daily at 24 hour intervals. The maximum dose is 20 mg daily.
The usual dose for treating agitation due to schizophrenia or bipolar disorder is 10 mg administered by intramuscular injection (immediate release). Additional 10 mg doses may be administered, but the efficacy of total doses greater than 30 mg daily have not been adequately evaluated.
The recommended treatment for resistant depression is 5-20 mg of olanzapine combined with 20-50 mg of fluoxetine once daily in the evening while the recommended treatment for depression associated with bipolar disorder is 5-12.5 mg olanzapine combined with 20-50 mg fluoxetine once daily in the evening.
Which drugs or supplements interact with olanzapine?
: Carbamazepine (Tegretol) can reduce blood concentrations of olanzapine, possibly necessitating higher doses of olanzapine. Other drugs that may also reduce blood levels of olanzapine are omeprazole (Prilosec) and rifampin.
Smoking may reduce blood concentrations of olanzapine.
Ciprofloxacin (Cipro), diltiazem (Cardizem, Dilacor, Tiazac), erythromycin, and fluvoxamine (Luvox) may have the opposite effect, that is, they may increase blood levels of olanzapine, and the dose of olanzapine may need to be reduced.
Olanzapine can cause orthostatic hypotension, a drop in blood pressure upon standing up that may cause dizziness or even fainting. Taking olanzapine with either diazepam (Valium), other related benzodiazepines or alcohol can exaggerate the orthostatic hypotension caused by olanzapine.
Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment
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