GENERIC NAME: olanzapine
BRAND NAME: Zyprexa, Zyprexa Zydis, Zyprexa Relprevv
DRUG CLASS AND MECHANISM: Olanzapine is a drug that is used to treat schizophrenia and acute manic episodes associated with bipolar I disorder. Olanzapine belongs to a drug class known as atypical antipsychotics. Other members of this class include clozapine (Clozaril), risperidone (Risperdal), aripiprazole (Abilify) and ziprasidone (Geodon). The exact mechanism of action of olanzapine is not known. It may work by blocking receptors for several neurotransmitters (chemicals that nerves use to communicate with each other) in the brain. It binds to alpha-1, dopamine, histamine H-1, muscarinic, and serotonin type 2 (5-HT2) receptors. Olanzapine was approved by the FDA in 1996.
PRESCRIBED FOR: Olanzapine is used for treating schizophrenia and acute mixed or manic episodes associated with bipolar disorder. It also is used as maintenance therapy for bipolar disorder and treating agitation due to schizophrenia or bipolar disorder. Olanzapine also is used in combination with fluoxetine (Prozac) for treatment of resistant depression and treatment of depression associated with bipolar disorder.
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