Ofloxacin should be avoided in children and adolescents under 18 years of age, as safe use in these patients have not been established.
Many antibiotics, including ofloxacin, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium responsible for the development of inflammation of the colon (Clostridium difficile, pseudomembranous colitis). Pseudomembranous colitis can cause fever, abdominal pain, diarrhea, and sometimes even shock.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 200, 300, and 400mg.
STORAGE: Ofloxacin should be stored in a closed container at 15 C - 30 C (59 F - 86 F).
DOSING: The usual dose for patients with normal renal function is 200 to 400 mg every 12 hours. Dosages require adjustment in patients with severely abnormal liver or kidney function.
DRUG INTERACTIONS: Ofloxacin reduces the elimination of theophylline, elevating blood levels of theophylline. (Theophylline is used to open airways in the treatment of asthma.) If concurrent use of ofloxacin and theophylline cannot be avoided, frequent blood tests to monitor theophylline blood levels should be performed. Ofloxacin can enhance the action of the anticoagulant (blood thinner) warfarin (Coumadin), and increase the risk of bleeding. Both high and low blood sugar levels have been reported, especially in patients with diabetes who were also receiving insulin or other medications used to lower the blood sugar. Careful monitoring of blood sugar levels is recommended. Sucralfate (Carafate), iron, multivitamins containing zinc, didanosine (Videx), as well as antacids containing calcium, magnesium, or aluminum should not be taken within two hours before or after taking ofloxacin.
Quick GuideCOPD Lung Symptoms, Diagnosis, Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.