ofloxacin, Floxin (Discontinued Brand) (cont.)

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DOSING: The usual dose for patients with normal renal function is 200 to 400 mg every 12 hours. Dosages require adjustment in patients with severely abnormal liver or kidney function.

DRUG INTERACTIONS: Ofloxacin reduces the elimination of theophylline, elevating blood levels of theophylline. (Theophylline is used to open airways in the treatment of asthma.) If concurrent use of ofloxacin and theophylline cannot be avoided, frequent blood tests to monitor theophylline blood levels should be performed. Ofloxacin can enhance the action of the anticoagulant (blood thinner) warfarin (Coumadin), and increase the risk of bleeding. Both high and low blood sugar levels have been reported, especially in patients with diabetes who were also receiving insulin or other medications used to lower the blood sugar. Careful monitoring of blood sugar levels is recommended. Sucralfate (Carafate), iron, multivitamins containing zinc, didanosine (Videx), as well as antacids containing calcium, magnesium, or aluminum should not be taken within two hours before or after taking ofloxacin.

PREGNANCY: Ofloxacin should be avoided during pregnancy because it is secreted in breast milk and can cause adverse events in the infant.

NURSING MOTHERS: Ofloxacin should be avoided in nursing mothers, as safe use has not been established.

SIDE EFFECTS: The most frequent side effects of ofloxacin include nausea, vomiting, diarrhea, insomnia, headache, dizziness, itching, and vaginitis in women.



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