ofloxacin, Floxin (Discontinued Brand)

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GENERIC NAME: ofloxacin

BRAND NAME: Floxin (discontinued brand)

DRUG CLASS AND MECHANISM: Ofloxacin is an antibiotic that is used to treat bacterial infections. It belongs to the fluoroquinolone class of antibiotics which includes levofloxacin (Levaquin), ciprofloxacin (Cipro), gatifloxacin (Tequin), norfloxacin (Noroxin), moxifloxacin (Avelox), trovafloxacin (Trovan) and others. Ofloxacin stops the multiplication of bacteria by inhibiting the reproduction and repair of their genetic material (DNA). The FDA approved ofloxacin in December 1990.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 200, 300, and 400mg.

STORAGE: Ofloxacin should be stored in a closed container at 15-30 C (59-86 F).

PRESCRIBED FOR: Ofloxacin is used to treat pneumonia and bronchitis caused by Haemophilus influenzae and Streptococcus pneumoniae. It also is used in treating skin infections caused by Staphylococcus aureus, and Streptococcus pyogenes bacteria. Ofloxacin is used to treat sexually transmitted diseases, such as gonorrhea and chlamydia, but is not effective against syphilis. Ofloxacin is used often to treat urinary infections and prostate infections caused by E. Coli. Some strains of Streptococcus, Enterococcus, and anaerobic bacteria are resistant to ofloxacin.

DOSING: The usual dose for patients with normal renal function is 200 to 400 mg every 12 hours. Dosages require adjustment in patients with severely abnormal liver or kidney function.

DRUG INTERACTIONS: Ofloxacin reduces the elimination of theophylline, elevating blood levels of theophylline. (Theophylline is used to open airways in the treatment of asthma.) If concurrent use of ofloxacin and theophylline cannot be avoided, frequent blood tests to monitor theophylline blood levels should be performed. Ofloxacin can enhance the action of the anticoagulant (blood thinner) warfarin (Coumadin), and increase the risk of bleeding. Both high and low blood sugar levels have been reported, especially in patients with diabetes who were also receiving insulin or other medications used to lower the blood sugar. Careful monitoring of blood sugar levels is recommended. Sucralfate (Carafate), iron, multivitamins containing zinc, didanosine (Videx), as well as antacids containing calcium, magnesium, or aluminum should not be taken within two hours before or after taking ofloxacin.

PREGNANCY: Ofloxacin should be avoided during pregnancy because it is secreted in breast milk and can cause adverse events in the infant.




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