GENERIC NAME: octreotide acetate
BRAND NAME: Sandostatin, Sandostatin LAR
DRUG CLASS AND MECHANISM: Octreotide acetate is an injectable medicine that is very similar to the hormone somatostatin, which is naturally produced in the body that has several effects including inhibition of the release of hormones. Octreotide works in a similar fashion as somatostatin, but is degraded more slowly and is a stronger inhibitor of glucagon, growth hormone, and insulin release. Like somatostatin, octreotide also decreases the release of growth stimulating hormones, decreases blood flow to the digestive organs, and inhibits the release of digestive hormones such as serotonin, gastrin, vasoactive intestinal peptide, secretin, motilin, and pancreatic polypeptide. Based on these actions, octreotide acetate is used to treat symptoms of severe diarrhea and flushing caused by cancer.
Octreotide is also used to treat acromegaly. Acromegaly is a rare hormonal disorder that affects adults in which there is an over production of growth hormone that leads to the abnormal growth of the hands, feet, or facial features. Octreotide significantly decreases the levels of growth hormone and IGF-I (somatomedin C) in patients with acromegaly.
The FDA approved octreotide acetate in October 1988.
PRESCRIBED FOR: Octreotide acetate is a prescription medicine used to treat certain patients with acromegaly. Specially, octreotide acetate is used to treat acromegaly in patients who have responded inadequately to or tare not candidates for surgery, pituitary irradiation, or treatment with high dose bromocriptine mesylate (Cycloset) therapy.
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