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- What is octreotide-injection, and how does it work (mechanism of action)?
- What brand names are available for octreotide-injection?
- Is octreotide-injection available as a generic drug?
- Do I need a prescription for octreotide-injection?
- What are the side effects of octreotide-injection?
- What is the dosage for octreotide-injection?
- Which drugs or supplements interact with octreotide-injection?
- Is octreotide-injection safe to take if I'm pregnant or breastfeeding?
- What else should I know about octreotide-injection?
What is octreotide-injection, and how does it work (mechanism of action)?
Octreotide acetate is an injectable medicine that is very similar to the hormone somatostatin, which is naturally produced in the body that has several effects including inhibition of the release of hormones. Octreotide works in a similar fashion as somatostatin, but is degraded more slowly and is a stronger inhibitor of glucagon, growth hormone, and insulin release. Like somatostatin, octreotide also decreases the release of growth stimulating hormones, decreases blood flow to the digestive organs, and inhibits the release of digestive hormones such as serotonin, gastrin, vasoactive intestinal peptide, secretin, motilin, and pancreatic polypeptide. Based on these actions, octreotide acetate is used to treat symptoms of severe diarrhea and flushing caused by cancer.
Octreotide is also used to treat acromegaly. Acromegaly is a rare hormonal disorder that affects adults in which there is an over production of growth hormone that leads to the abnormal growth of the hands, feet, or facial features. Octreotide significantly decreases the levels of growth hormone and IGF-I (somatomedin C) in patients with acromegaly.
The FDA approved octreotide acetate in October 1988.
What brand names are available for octreotide-injection?
Sandostatin, Sandostatin LAR
Is octreotide-injection available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for octreotide-injection?
What are the side effects of octreotide-injection?
Side effects reported with octreotide include:
- gallbladder problems,
- slow heart rate (bradycardia),
- irregular heartbeat (arrhythmias),
- stomach pain,
- gas (flatulence),
- abnormal stools,
- stomach distention,
- low and high blood glucose,
- low thyroid levels,
- injection site pain, and
Other side effects that occurred in 1% to 4% of patients included:
- joint pain,
- urinary tract infection (UTI),
- cold symptoms,
- flu symptoms,
- injection site hematoma,
- blurred vision,
- fat malabsorption,
- hair loss,
- visual disturbance, and
Other side effects include:
- increase in liver enzymes,
- gastrointestinal (GI) bleeding,
- gastric or peptic ulcer,
- gallbladder polyp,
- superficial skin infections,
- basal cell carcinoma (skin cancer),
- joint effusion,
- muscle pain,
- Raynaud's phenomenon,
- chest pain,
- shortness of breath,
- congestive heart failure,
- high blood pressure,
- hypertensive reaction,
- heart palpitations,
- orthostatic hypotension,
- low sex drive (low libido),
- fainting (syncope),
- Bell's Palsy,
- pituitary apoplexy,
- increased intraocular pressure,
- hearing loss,
- pulmonary nodule,
- status asthmaticus,
- diabetes insipidus,
- iron deficiency,
- ear infection (otitis),
- allergic reaction,
- increased creatine kinase, and
- weight loss.
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