nortriptyline, Pamelor, Aventyl (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Combining nortriptyline or other TCAs with drugs that block acetylcholine (anticholinergic drugs) can cause constipation and even paralyze the intestine (paralytic ileus). Dangerous elevations in blood pressure may occur if TCA's are combined with clonidine (Catapres, Catapres-TTS).

PREGNANCY: Safe use of nortriptyline during pregnancy has not been established Physicians may use nortriptyline in pregnant women if its benefits are deemed to outweigh its potential but unknown risks.

NURSING MOTHERS: Safe use of nortriptyline during lactation has not been established. It is not known if nortriptyline is secreted in breast milk.

SIDE EFFECTS: The most commonly encountered side effects associated with nortriptyline include fast heart rate, blurred vision, urinary retention, dry mouth, constipation, weight gain or loss, and low blood pressure on standing. Rash, hives, seizures, and hepatitis are rare side effects. Nortriptyline also can cause elevated pressure in the eyes of some patients with glaucoma. Overdoses of nortriptyline can cause life-threatening abnormal heart rhythms or seizures.

Reference: FDA Prescribing Information

Last Editorial Review: 4/15/2009

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