nortriptyline, Pamelor, Aventyl - has been discontinued in the U.S. (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:
Medical and Pharmacy Editor:

Individuals with depression may have an imbalance in neurotransmitters, chemicals that nerves make and use to communicate with other nerves. Like all TCAs, nortriptyline increases levels of norepinephrine and serotonin, two neurotransmitters, and blocks the action of acetylcholine, another neurotransmitter. It is believed that by restoring the balance of these different neurotransmitters in the brain depression is alleviated (for example, the mood is elevated).

Nortriptyline was approved by the FDA in November 1964.

PRESCRIBED FOR: Nortriptyline is used to elevate the mood of patients with depression.

Non-FDA approved (off-label) use of nortriptyline includes:

Adjunctive therapy (added to other therapy) for chronic pain, for example,

SIDE EFFECTS: The most commonly encountered side effects associated with nortriptyline include:

Medically Reviewed by a Doctor on 12/19/2014

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.

Back to Medications Index

Health Solutions From Our Sponsors