- What is nortriptyline, and how does it work (mechanism of action)?
- What brand names are available for nortriptyline?
- Is nortriptyline available as a generic drug?
- Do I need a prescription for nortriptyline?
- What are the side effects of nortriptyline?
- What is the dosage for nortriptyline?
- Which drugs or supplements interact with nortriptyline?
- Is nortriptyline safe to take if I'm pregnant or breastfeeding?
- What else should I know about nortriptyline?
What is the dosage for nortriptyline?
Which drugs or supplements interact with nortriptyline?
TCAs, including nortriptyline, should not be used concurrently with a monoamine oxidase inhibitors such as tranylcypromine (Parnate), isocarboxazid (Marplan), phenelzine (Nardil), and procarbazine (Matulane) because of the possibility of hyperpyretic crises (high fever), convulsions, and even death.
Cimetidine (Tagamet) can increase blood levels of nortriptyline in the blood by interfering with the metabolism (breakdown) of nortriptyline by the liver. Increased levels of nortriptyline may possibly lead to side effects. Other drugs which share this effect on nortriptyline include propafenone (Rythmol), flecainide (Tonocard), quinidine (Quinidex, Quinaglute), and fluoxetine (Prozac).
Nortriptyline exaggerates the effects of other medications and drugs that slow the activity of the brain, such as alcohol, barbiturates, benzodiazepines, for example lorazepam (Ativan), clonazepam (Klonopin), and diazepam (Valium), as well as narcotics. Reserpine (Harmonyl), stimulates the brain when given to patients taking nortriptyline.
Combining nortriptyline or other TCAs with drugs that block acetylcholine (anticholinergic drugs) can cause constipation and even paralyze the intestine (paralytic ileus). Dangerous elevations in blood pressure may occur if TCA's are combined with clonidine (Catapres, Catapres-TTS).
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