nortriptyline, Pamelor, Aventyl - has been discontinued in the U.S. (cont.)

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Individuals with depression may have an imbalance in neurotransmitters, chemicals that nerves make and use to communicate with other nerves. Like all TCAs, nortriptyline increases levels of norepinephrine and serotonin, two neurotransmitters, and blocks the action of acetylcholine, another neurotransmitter. It is believed that by restoring the balance of these different neurotransmitters in the brain depression is alleviated (for example, the mood is elevated).

Nortriptyline was approved by the FDA in November 1964.

PRESCRIBED FOR: Nortriptyline is used to elevate the mood of patients with depression.

Non-FDA approved (off-label) use of nortriptyline includes:

Adjunctive therapy (added to other therapy) for chronic pain, for example,

SIDE EFFECTS: The most commonly encountered side effects associated with nortriptyline include:

Medically Reviewed by a Doctor on 12/19/2014

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