norfloxacin, Noroxin (cont.)
NURSING MOTHERS: It is not known whether norfloxacin enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.
Children and adolescents: The safety and efficacy of the drug in pediatric or adolescents (under age 18) has not been established.
Norfloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. Many antibiotics, including norfloxacin, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium responsible for the development of inflammation of the colon, (C. difficile caused pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting norfloxacin (diarrhea, fever, abdominal pain, and possibly shock) should contact their doctor immediately.
Fluoroquinolones have neuromuscular blocking activity and can worsen muscles weakness in individuals with myasthenia gravis. They also worsen low blood glucose levels when combined with sulfonylureas (for example, glyburide [Micronase, Diabeta, Glynase, Prestab]).
REFERENCE: FDA Prescribing Information.
Medically Reviewed by a Doctor on 10/24/2014
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