norfloxacin, Noroxin

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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DOSING:

  • Uncomplicated urinary tract infection: Take 1 tablet (400 mg) by mouth every 12 hours for 3 days
  • Complicated urinary tract infection: Take 1 tablet (400 mg) by mouth every 12 hours for 10 to 21 days.
  • For infections caused by E. coli, K. pneumoniae, or P. mirabilis only. Take 1 tablet (400 mg) by mouth every 12 hours for 7 to 10 days, for infections caused by any other bacteria.
  • Prostatitis: Take 1 tablet (400 mg) by mouth every 12 hours for 28 to 42 days.
  • Gonorrhea: Take 2 tablets (800 mg) by mouth as one single dose.

Safe and effective use of norfloxacin is not established in patients under the age of 18 years.

Note that some organisms are resistant to norfloxacin; organisms should be tested for susceptibility to this drug.

DRUG INTERACTIONS: Norfloxacin should be used with caution with medications like caffeine, clozapine (Clozaril), ropinorole (Requip), cyclosporine (Neoral, Sandimmune, Gengraf), theophylline (Theo-24), and tizanidine (Zanaflex) because norfloxacin can slow down breakdown of these medications in and increase their levels in the body.

Norfloxacin should be separated from aluminum and magnesium containing antacids, sucralfate (Carafate), and multivitamins because they can lower absorption of norfloxacin and reduce its effectiveness. They should be administered 2 hours before norfloxacin.

Medically Reviewed by a Doctor on 10/24/2014

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