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- What is norfloxacin-oral, and how does it work (mechanism of action)?
- What brand names are available for norfloxacin-oral?
- Is norfloxacin-oral available as a generic drug?
- Do I need a prescription for norfloxacin-oral?
- What are the side effects of norfloxacin-oral?
- What is the dosage for norfloxacin-oral?
- Which drugs or supplements interact with norfloxacin-oral?
- Is norfloxacin-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about norfloxacin-oral?
What is norfloxacin-oral, and how does it work (mechanism of action)?
Norfloxacin is a fluoroquinolone antibiotic. Other fluoroquinolones include ciprofloxacin (Cipro), levofloxacin (Levaquin), and ofloxacin (Floxin). Norfloxacin works by blocking DNA gyrase enzyme, which is responsible for production and repair of bacterial DNA. Blocking of DNA gyrase leads to bacteria death and prevents worsening of infection. Norfloxacin treats infections caused by gram-positive and gram-negative bacteria like Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus agalactiae, Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumonia, Neisseria gonorrhoeae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, and Serratia marcescens. FDA approved the brand name norfloxacin (Noroxin) in October 1986.
What brand names are available for norfloxacin-oral?
Is norfloxacin-oral available as a generic drug?
GENERIC AVAILABLE: Not in US, in Canada
Do I need a prescription for norfloxacin-oral?
What are the side effects of norfloxacin-oral?
Norfloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. Many antibiotics, including norfloxacin, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium responsible for the development of inflammation of the colon, (C. difficile caused pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting norfloxacin (diarrhea, fever, abdominal pain, and possibly shock) should contact their doctor immediately.
Fluoroquinolones have neuromuscular blocking activity and can worsen muscles weakness in individuals with myasthenia gravis. They also worsen low blood glucose levels when combined with sulfonylureas (for example, glyburide [Micronase, Diabeta, Glynase, Prestab]).
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