norethindrone (Aygestin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

What is norethindrone-oral, and how does it work (mechanism of action)?

Norethindrone is a man-made progestin used for treating abnormal uterine bleeding and related condtions (such as amenorrhea and endometriosis). Progestins are steroid hormones that have the same effect as progesterone. Norethindrone works by stopping gonadotropin production from the pituitary gland, leading to prevention of ovulation in females. The FDA approved norethindrone in April, 1982.

What brand names are available for norethindrone-oral?

Aygestin

Is norethindrone-oral available as a generic drug?

Yes

Do I need a prescription for norethindrone-oral?

Yes

What are the side effects of norethindrone-oral?

Side effects of norethindrone are: 

  • edema,
  • nausea,
  • breast tenderness,
  • irregular menstrual cycle,
  • breakthrough bleeding,
  • spotting,
  • weight change, and
  • headache.

Deep vein thrombosis and depression may also occur.

Medically Reviewed by a Doctor on 5/11/2017

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