GENERIC NAME: nizatidine
BRAND NAME: Axid
DRUG CLASS AND MECHANISM: Histamine is a natural
chemical that
stimulates stomach cells to produce acid. Nizatidine belongs to
a class of
medications called H2-blockers that inhibit the action of
histamine on
stomach cells, thus reducing stomach acid production.
PRESCRIPTION: Yes
GENERIC AVAILABLE: Yes
PREPARATIONS: pulvules: 150 mg, 300 mg
STORAGE: Should be stored at room temperature in
tightly closed
container.
PRESCRIBED FOR: Nizatidine blocks the action of
histamine on
stomach cells, and reduces stomach acid production. Nizatidine
is useful
in promoting healing of stomach and duodenal ulcers, and in
reducing ulcer
pain. Nizatidine has been effective in preventing ulcer
recurrence when
given in low doses for prolonged periods of time. In doses
higher than
that used in ulcer treatment, nizatidine has been helpful in
treating
heartburn and in healing ulcer and inflammation of the
esophagus resulting
from acid reflux (reflux esophagitis).
DOSING: May be taken with or without food.
DRUG INTERACTIONS: Nizatidine is generally well
tolerated and
safe. Safe use in children has not been established. A
beneficial symptom
response to nizatidine does not preclude the presence of
stomach cancer.
The dose of nizatidine is usually reduced in severe kidney
failure to
avoid excessive blood levels. This medication is not habit
forming.
PREGNANCY: Safe use during pregnancy has not been
established.
NURSING MOTHERS: The medication is secreted in milk and
is
generally discouraged in nursing mothers.
SIDE EFFECTS: Side effects are rare. Minor side effects
include
constipation, diarrhea, fatigue, headache, insomnia, muscle
pain, nausea,
and vomiting. Major side effects include agitation, anemia,
confusion,
depression, enlargement of the breasts, easy bruising or
bleeding,
hallucinations, hair loss, irregular heartbeat, impotence, rash, visual
changes, and yellowing of the skin or eyes.
Last Editorial Review: 12/31/1997
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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