nitrofurantoin, Macrodantin, Furadantin, Macrobid (cont.)

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NURSING MOTHERS: Nitrofurantoin is distributed into breast milk and should be used with caution in women who are breastfeeding.

SIDE EFFECTS: Common side effects include headache, rash, itching, nausea, vomiting, loss of appetite, diarrhea, and abdominal pain. The macrocrystalline form (Macrodantin) appears to cause less stomach upset. Stomach upset also can be minimized by using a lower dose or by taking nitrofurantoin with food or milk.

Nitrofurantoin can cause serious lung injury. The reaction can occur within hours of the start of treatment if the patient has previously received nitrofurantoin, or within a few days of starting nitrofurantoin for the first time. Symptoms include:

In other persons, lung injury may occur after approximately a month of treatment. Symptoms include:

  • difficulty breathing,
  • rapid breathing, and
  • cough.

Fortunately, the symptoms usually resolve within a week if the medication is stopped. In other individuals, lung injury may not develop until after several months or years of therapy. Unless it is recognized and treated, this delayed lung injury can result in permanent lung damage that remains even after the drug is stopped.

Medically Reviewed by a Doctor on 10/24/2014

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