nisoldipine, Sular (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Nisoldipine is used to treat high blood pressure. It may be used alone or in combination with other agents.

DOSING: The recommended dose is 17 to 34 mg or 20 to 40 mg daily depending on the formulation that is used. Doses may be increased at one week intervals. Tablets should be swallowed whole and taken on an empty stomach. Individuals with poor liver function require lower doses of nisoldipine.

DRUG INTERACTIONS: Cimetidine (Tagamet) or any drug that reduces the activity of liver enzymes that break down nisoldipine can increase blood levels of nisoldipine, possibly causing more side effects. Examples of drugs that may reduce break down of nisoldipine include ketoconazole, itraconazole (Sporanox), and erythromycin.

PREGNANCY: The effects of nisoldipine in pregnancy are unknown.

NURSING MOTHERS: It is unknown if nisoldipine appears in breast milk.

SIDE EFFECTS: Peripheral edema (swollen ankles and feet), headache, dizziness, nausea, palpitations are the most common side effects of nisoldipine. Hypersensitivity reactions, worsening of chest pain, low blood pressure, and heart attacks have also been reported.

Reference: FDA Prescribing Information


Last Editorial Review: 8/1/2012



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