nilotinib, Tasigna (cont.)

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Other important side effects caused by Nilotinib include:

Nilotinib may cause a type of abnormal heart rhythm called prolongation of QT interval. Prolongation of the QT interval may lead to sudden death. ECGs should be obtained prior to starting nilotinib, 7 days after start of treatment, after dose adjustments, and as needed thereafter. Low potassium or low magnesium may increase the risk of QT prolongation. Therefore, low potassium and low magnesium should be corrected prior to starting treatment. Food and/or drugs that reduce break down of nilotinib in the liver and/or medicinal products that prolong QT interval may increase the risk of QT prolongation and should not be combined with nilotinib.



PREPARATIONS: Capsules: 150 and 200 mg

STORAGE: Nilotinib should be stored nilotinib at room temperature between 15 C - 30 C (59 F - 86 F).

DOSING: The recommended dose range is 300 mg or 400 mg orally twice daily taken 12 hours apart. Each capsule should be swallowed whole with water or sprinkle contents of capsule on one teaspoon of applesauce. Food increases the blood concentration of nilotinib. Therefore, nilotinib should be taken on an empty stomach, at least 2 hours after eating any food and individuals should wait one hour after taking nilotinib before eating any food.

DRUG INTERACTIONS: The blood concentration of nilotinib may be increased by several drugs that reduce its break down by the liver. Examples include amiodarone (Cordarone), disopyramide, procainamide, quinidine, and sotalol. Increased blood concentrations of nilotinib may increase the occurrence of adverse effects.

Medically Reviewed by a Doctor on 5/27/2015

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