nilotinib, Tasigna (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: The blood concentration of nilotinib may be increased by several drugs that reduce its break down by the liver. Examples include amiodarone (Cordarone), disopyramide, procainamide, quinidine, and sotalol. Increased blood concentrations of nilotinib may increase the occurrence of adverse effects.

Certain drugs decrease the concentration of nilotinib resulting in decreased blood levels and possibly reduced effect. Examples include dexamethasone, carbamazepine, phenobarbital, rifampin, rifabutin, rifapentin, phenytoin, and St John's Wort.

Food increases the blood concentration of nilotinib. Therefore, nilotinib should be taken on an empty stomach, at least 2 hours after eating any food. Individuals should wait one hour after taking nilotinib before eating any food.

PREGNANCY: Nilotinib is harmful to the fetus and should not be used during pregnancy.

NURSING MOTHERS: It is not known whether nilotinib is excreted in human milk. Some related drugs are excreted in breast milk. To avoid any risk to the infant, nursing mothers should consider discontinuing nursing or nilotinib.

Medically reviewed by Eni Williams, PharmD

Medically Reviewed by a Doctor on 5/27/2015

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