nicardipine, Cardene, Cardene SR (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: Yes
PREPARATIONS: Capsules: 20 and 30 mg; Sustained release capsules:30 and 60 mg; Injection 0.1, 0.2 and 2.5 mg
STORAGE: Nicardipine should be stored at room temperature, 15 to 30 C (59 to 86 F), and protected from light.
PRESCRIBED FOR: Oral nicardipine is used alone or in combination with other drugs for the treatment of high blood pressure. Conventional capsules (not sustained release) also are used for the treatment of angina (chest pain). Nicardipine injections are used for short-term treatment of blood pressure when oral medications are not possible or desirable.
DOSING: The recommended dose of nicardipine for treatment of hypertension is 20-40 mg three times daily with conventional capsules or 30-60 mg twice daily with sustained release capsules. Intravenous infusion rates can range between 0.5 and 15 mg/hr. Chest pain is treated with 20-40 mg of conventional capsules three times daily.
DRUG INTERACTIONS: Rifampin, phenobarbital, phenytoin (Dilantin, Dilantin-125), oxcarbazepine (suspension oral Trileptal; oral Trileptal) and carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol) may reduce blood levels of nicardipine by increasing its metabolism (destruction) in the liver. Therapy should be monitored and drug doses should be adjusted accordingly when nicardipine is used with these drugs.
Co-administration of nicardipine and cyclosporine results in increased cyclosporine blood levels. Cyclosporine blood levels should be monitored and its dosage reduced when taking nicardipine.
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