NIACIN EXTENDED-RELEASE/LOVASTATIN-ORAL (cont.)
DRUG INTERACTIONS: See also the How To Use section. This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: certain azole antifungals (e.g., itraconazole, ketoconazole), delavirdine, HIV protease inhibitors (e.g., ritonavir, amprenavir, lopinavir), certain macrolide antibiotics (e.g., erythromycin, clarithromycin, troleandomycin), mibefradil, nefazodone, telithromycin. If you are currently using any of these medications, tell your doctor or pharmacist before starting this product. Use caution if the following drugs are combined with this medication because serious side effects such as muscle injury (myopathy) infrequently could occur: fibrates (e.g., gemfibrozil, fenofibrate). Even though this product contains niacin, doses of niacin above 1 gram per day infrequently have caused muscle injury (myopathy) with or without lovastatin use. Consult your doctor for more details. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: azithromycin, "blood thinners" (e.g., warfarin), cholestyramine, colestipol, drugs for high blood pressure, other niacin and related products (e.g., vitamin products, nicotinamide), other drugs which affect certain liver enzymes (CYP 3A4 substrates, inhibitors, and inducers such as amiodarone, cyclosporine, diltiazem, verapamil, rifampin, St. John's wort, carbamazepine). This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without doctor or pharmacist approval.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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