nevirapine, Viramune, Viramune XR (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Nevirapine reduces blood concentrations of atazanavir (Reyataz), efavirenz (Sustiva), clarithromycin (Biaxin), amprenavir (Agenerase), indinavir (Crixivan), ketoconazole, itraconzole (sporanox), and lopinavir (Kaletra).
Atazanavir (Reyataz), fluconazole (Diflucan), and fosamprenavir increase blood levels of nevirapine.
Rifampin (Rifadin), rifabutin (Mycobutin), ketoconazole (Nizoral) and St. John's Wort decrease blood concentrations of nevirapine by increasing its breakdown. Decreased blood concentration may reduce the effectiveness of nevirapine.
Nevirapine reduces the blood concentration of oral contraceptives, and this could result in inadequate birth control. Nevirapine also decreases the concentration of methadone (Dolophine) and this could lead to narcotic withdrawal symptoms.
PREGNANCY: There are no adequate studies of nevirapine in pregnant women.
NURSING MOTHERS: Nevirapine is excreted in human breast milk. Nursing should be discontinued during nevirapine therapy. In addition, HIV infected mothers should not nurse because of the risk of transmitting HIV to an infant that is not infected.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 7/10/2015
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