nevirapine, Viramune, Viramune XR (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Nevirapine reduces the blood concentration of oral contraceptives, and this could result in inadequate birth control. Nevirapine also decreases the concentration of methadone (Dolophine) and this could lead to narcotic withdrawal symptoms.
PREGNANCY: There are no adequate studies of nevirapine in pregnant women.
NURSING MOTHERS: Nevirapine is excreted in human breast milk. Nursing should be discontinued during nevirapine therapy. In addition, HIV infected mothers should not nurse because of the risk of transmitting HIV to an infant that is not infected.
SIDE EFFECTS: The most common side effects of nevirapine are rash, headaches, diarrhea, nausea, fever, abdominal pain and muscle pain (myalgia). The most serious side effects are liver failure, severe skin reactions, decreased white blood cells, and muscle breakdown (rhabdomyolysis). Like other antiretroviral drugs, use of nevirapine is associated with redistribution or accumulation of body fat. Immune reconstitution syndrome which is an inflammatory response to infection may occur in patients treated with combination anti-HIV therapy.
Reference: FDA Prescribing Information
Last Editorial Review: 3/8/2013
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