DRUG INTERACTIONS: Nevirapine has several drug interactions because it is converted to inactive compounds by liver enzymes. Several drugs increase or decrease the activity of these enzymes. Conversely, nevirapine affects the breakdown of other drugs by the liver.
Nevirapine reduces blood concentrations of atazanavir (Reyataz), efavirenz (Sustiva), clarithromycin (Biaxin), amprenavir (Agenerase), indinavir (Crixivan), ketoconazole, itraconzole (sporanox), and lopinavir (Kaletra).
Rifampin (Rifadin), rifabutin (Mycobutin), ketoconazole (Nizoral) and St. John's Wort decrease blood concentrations of nevirapine by increasing its breakdown. Decreased blood concentration may reduce the effectiveness of nevirapine.
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