nesiritide-injection, Natrecor (cont.)

SIDE EFFECTS: Dizziness, lightheadedness, nausea, or headache may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: unusually fast or slow heartbeat, chest pain, back pain, stomach pain, vomiting, trouble sleeping, mental/mood changes. Tell your doctor immediately if any of these unlikely but serious side effects occur: fever, pain/swelling/redness of the injection site, tingling or numbness of the hands/feet, severe cough or coughing up blood, rash, leg cramps, vision problems, unusual tiredness or weakness, sweating. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: change in amount of urine. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: kidney problems, low blood pressure, any allergies. This medication is not recommended for use if you have the following medical conditions: very low blood pressure (systolic BP less than 90), shock due to poor heart function (cardiogenic shock), other serious heart conditions (e.g., valvular stenosis, constrictive pericarditis). To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medication you may use, especially: other drugs that may lower blood pressure (e.g., ACE inhibitors, beta- blockers, calcium channel blockers, diuretics, vasodilators). Do not mix this medication with heparin, through IV lines that have had heparin in them (e.g., heparin flushes), or through IV lines containing other injectable drugs. Heparin or other IV drugs, mixed together, could decrease the effectiveness of this drug. Use a separate IV line for heparin-containing solutions and other IV drugs, if needed. Do not start or stop any medicine without doctor or pharmacist approval.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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