neomycin sulfate, polymyxin B sulfate, hydrocortisone acetate (Cortisporin, Otimar, Pediotic)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

19 Habits That Wreck Your Teeth

GENERIC NAME: neomycin sulfate, polymyxin B sulfate, hydrocortisone acetate

BRAND NAME: Cortisporin, Otimar, Pediotic

DRUG CLASS AND MECHANISM: Neomycin sulfate/polymyxin B sulfate/ hydrocortisone acetate is an antibacterial and anti-inflammatory ear drop. Neomycin and polymyxin are antibiotics that are active against gram positive and gram negative bacteria like Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella-Enterobacter species, Neisseria species, and Pseudomonas aeruginosa. Neomycin inhibits protein synthesis in bacteria, leading to bacterial cell death. Polymyxin alters bacterial cell wall structure so that cellular contents leak out and causes the bacteria to die. Hydrocortisone suppresses inflammation in the affected area. The FDA approved neomycin sulfate/polymyxin B sulfate/ hydrocortisone acetate in March, 1957.

SIDE EFFECTS: Side effects of neomycin sulfate/polymyxin B sulfate/ hydrocortisone acetate are:

  • hypersensitivity,
  • itching,
  • redness,
  • swelling, and
  • skin rash.

PRESCRIBED FOR: Neomycin sulfate/polymyxin B sulfate/ hydrocortisone acetate ear drops are used for treating bacterial infections of the external ear canal.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Neomycin sulfate/polymyxin B sulfate/ hydrocortisone acetate ear drops are available in sterile suspension and solution forms in 10 ml bottles.

STORAGE: Neomycin sulfate/polymyxin B sulfate/ hydrocortisone acetate ear drops should be stored between 15 C to 25 C (59 F to 77 F).

DOSING:

  • Adults: Apply 4 drops into affected ear every 6 to 8 hours.
  • Infants and children: Apply 3 drops into affected ear every 6 to 8 hours.

The duration of treatment may last up to 10 days.

DRUG INTERACTIONS: There are no significant drug interactions with neomycin sulfate/polymyxin B sulfate/ hydrocortisone acetate.

Medically Reviewed by a Doctor on 1/29/2015
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