neomycin sulfate, polymyxin B sulfate, hydrocortisone acetate (Cortisporin, Otimar, Pediotic)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is neomycin-polymyxin-hydrocortisone-otic suspension, and how does it work (mechanism of action)?

Neomycin sulfate/polymyxin B sulfate/ hydrocortisone acetate is an antibacterial and anti-inflammatory ear drop. Neomycin and polymyxin are antibiotics that are active against gram positive and gram negative bacteria like Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella-Enterobacter species, Neisseria species, and Pseudomonas aeruginosa. Neomycin inhibits protein synthesis in bacteria, leading to bacterial cell death. Polymyxin alters bacterial cell wall structure so that cellular contents leak out and causes the bacteria to die. Hydrocortisone suppresses inflammation in the affected area. The FDA approved neomycin sulfate/polymyxin B sulfate/ hydrocortisone acetate in March, 1957.

What brand names are available for neomycin-polymyxin-hydrocortisone-otic suspension?

Cortisporin, Otimar, Pediotic

Is neomycin-polymyxin-hydrocortisone-otic suspension available as a generic drug?


Do I need a prescription for neomycin-polymyxin-hydrocortisone-otic suspension?


What are the side effects of neomycin-polymyxin-hydrocortisone-otic suspension?

Side effects of neomycin sulfate/polymyxin B sulfate/ hydrocortisone acetate are:

  • hypersensitivity,
  • itching,
  • redness,
  • swelling, and
  • skin rash.

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