nelfinavir, Viracept (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Rifampin and St. John's wort decrease the concentration of nelfinavir in the body and may reduce the effectiveness of nelfinavir.

Nelfinavir may decrease the effectiveness of oral contraceptives.

PREGNANCY: Nelfinavir has not been adequately evaluated in pregnant women.

NURSING MOTHERS: It is not known whether nelfinavir is secreted in breast milk. Nevertheless, HIV-infected mothers should not breastfeed because of the potential risk of transmitting HIV to an infant that is not infected.

SIDE EFFECTS: The most common side effects are nausea, diarrhea, flatulence, allergic reactions, and rash. Nelfinavir may also cause jaundice, metabolic disturbance, liver failure and failure of the pancreas (pancreatitis). Nelfinavir oral powder contains phenylalanine and should be avoided by individuals with phenylketonuria. Like other protease inhibitors, use of nelfinavir may be associated with redistribution or accumulation of body fat, increased cholesterol and worsening of diabetes. Immune reconstitution syndrome, an inflammatory response to infection, may occur in patients treated with combinations of drugs for the treatment of HIV infection. There have been reports of spontaneous bleeding in patients with hemophilia treated with protease inhibitors.

Reference: FDA Prescribing Information

Last Editorial Review: 3/25/2013

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