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- What is nelfinavir, and how does it work (mechanism of action)?
- What brand names are available for nelfinavir?
- Is nelfinavir available as a generic drug?
- Do I need a prescription for nelfinavir?
- What are the side effects of nelfinavir?
- What is the dosage for nelfinavir?
- Is nelfinavir safe to take if I'm pregnant or breastfeeding?
- What else should I know about nelfinavir?
What is nelfinavir, and how does it work (mechanism of action)?
Nelfinavir is an oral medication that is used for treating infections with the human immunodeficiency virus (HIV). It is in a class of drugs called protease inhibitors that also includes indinavir (Crixivan), amprenavir (Agenerase), ritonavir (Norvir) and saquinavir (Invirase, Fortovase). During infection with HIV, the HIV virus multiplies within the body's cells. Viruses are released from the cells and spread throughout the body where they infect other cells. In this manner, HIV infection is perpetuated among new cells that the body continually produces. During the production of the viruses, new proteins are made. Some of the proteins are structural proteins, that, is, proteins that form the body of the virus. Other proteins are enzymes which manufacture DNA and other components for the new viruses. Protease is the enzyme that forms the new structural proteins and enzymes. Nelfinavir blocks the activity of protease and results in the formation of defective viruses that are unable to infect the body's cells. As a result, the number of viruses in the body (the viral load) decreases. Nevertheless, nelfinavir does not prevent the transmission of HIV among individuals, and it does not cure HIV infections or AIDS. Nelfinavir was approved by the FDA in March 1997.
What brand names are available for nelfinavir?
Is nelfinavir available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for nelfinavir?
What are the side effects of nelfinavir?
The most common side effects are
Other important side effects Nelfinavir include:
Nelfinavir oral powder contains phenylalanine and should be avoided by individuals with phenylketonuria. Like other protease inhibitors, use of nelfinavir may be associated with redistribution or accumulation of body fat, increased cholesterol and worsening of diabetes. Immune reconstitution syndrome, an inflammatory response to infection, may occur in patients treated with combinations of drugs for the treatment of HIV infection. There have been reports of spontaneous bleeding in patients with hemophilia treated with protease inhibitors.
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