nefazodone, Serzone (cont.)

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Medical and Pharmacy Editor:

Carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol) may decrease nefazodone blood levels and possibly its effectiveness by increasing nefadone's removal by the liver. Conversely, nefazodone may increase the levels of carbamazepine, possibly leading to toxicity, by decreasing the removal of carbamazepine by the liver.

PREGNANCY: There are no adequate studies of nefazodone in pregnant women.

NURSING MOTHERS: Nefazodone may be secreted in breast milk and may cause adverse effects in the nursing infant.

SIDE EFFECTS: The most commonly noted side effects associated with nefazodone are nausea, dizziness, insomnia, agitation, tiredness, dry mouth, constipation, lightheadedness, blurred vision, and confusion. Rarely, nefazodone is associated with priapism or prolonged penile erection. Compared with trazodone, nefazodone has a lesser risk of priapism (prolonged penile erection). Although the erection usually subsides eventually, occasionally blood clots form within the penis and cause serious damage to the penis. Nefazodone rarely may cause liver failure that may result in liver transplantation.

If antidepressants are discontinued abruptly, symptoms may occur such as dizziness, headache, nausea, changes in mood, or changes in the sense of smell, taste, etc. (Such symptoms even may occur when even a few doses of antidepressant are missed.) Therefore, it is recommended that the dose of antidepressant be reduced gradually when therapy is discontinued.

Medically Reviewed by a Doctor on 9/12/2014

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