Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
PREGNANCY: There are no adequate studies of nefazodone in
pregnant women.
NURSING MOTHERS: Nefazodone may be secreted in
breast milk and may cause
adverse effects in the nursing infant.
SIDE EFFECTS: The most commonly noted side effects associated with nefazodone
are nausea, dizziness, insomnia, agitation, tiredness, dry mouth, constipation,
lightheadedness, blurred vision, and confusion. Rarely, nefazodone is associated
with priapism or prolonged penile erection. Although the erection usually
subsides eventually, occasionally blood clots form within the penis and cause
serious damage to the penis. Nefazodone rarely may cause liver failure that may
result in liver transplantation.
If antidepressants are discontinued abruptly, symptoms may occur such as
dizziness, headache, nausea, changes in mood, or changes in the sense of smell,
taste, etc. (Such symptoms even may occur when even a few doses of
antidepressant are missed.) Therefore, it is recommended that the dose of
antidepressant be reduced gradually when therapy is discontinued.
Antidepressants increased the risk of suicidal thinking and behavior in
short-term studies in children and
adolescents with depression and other
psychiatric disorders. Anyone considering the use of nefazodone or any other
antidepressant in a child or adolescent must balance this
risk of suicide with
the clinical need. Patients who are started on therapy should be closely
observed for clinical worsening, suicidal thoughts, or unusual changes in
behavior.
Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).
Post-traumatic stress disorder (PTSD), a psychiatric condition, can develop after any catastrophic life event. Symptoms include nightmares, flashbacks, sweating, rapid heart rate, detachment, amnesia, sleep problems, irritability, and exaggerated startle response. Treatment may involve psychotherapy, group support, and medication.
Childhood depression can interfere with social activities, interests, schoolwork and family life. Symptoms and signs include anger, social withdrawal, vocal outbursts, fatigue, physical complaints, and thoughts of suicide. Treatment may involve psychotherapy and medication.
Postpartum depression is a form of depression that occurs within a year after delivery. It is thought that rapid hormone changes after childbirth may lead to depression. Symptoms of postpartum depression include crying a lot, headaches, chest pains, eating too little or too much, sleeping too little or too much, withdrawal from friends and family, and feeling irritable, sad, hopeless, worthless, guilty, and overwhelmed. Treatment typically involves talk therapy and medication.
Nightmares are dreams that cause high anxiety or terror. Nightmares may be a part of posttraumatic stress disorder (PTSD), and they usually occur during rapid eye movement (REM) sleep. There are several different treatment options for nightmares, including cognitive-behavioral therapy and medications.
Depression in teenagers may be caused by many factors. Symptoms of teen depression include apathy, irresponsible behavior, sadness, sudden drop in grades, withdrawal from friends, and alcohol and drug use. Treatment of depression in adolescents may involve psychotherapy and medications.
Depression in the elderly is very common. That doesn't mean, though, it's normal. Treatment may involve antidepressants, psychotherapy, or electroconvulsive therapy.
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