nefazodone, Serzone

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GENERIC NAME: nefazodone

BRAND NAME: Serzone (This brand no longer is available in the U.S.)

DRUG CLASS AND MECHANISM: Nefazodone is an oral antidepressant drug. Nefazodone affects chemicals in the brain that nerves use to send messages to one another, called neurotransmitters. The neurotransmitters that are released by nerves are taken up again by the nerves that release them for reuse. Many experts believe that depression is caused by an imbalance among the amounts of neurotransmitters that are released. Nefazodone works by inhibiting the uptake by nerves of serotonin and norepinephrine, two neurotransmitters, resulting in more serotonin and norepinephrine to transmit messages to other nerves. Nefazodone is chemically unrelated to the serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs), or the monoamine oxidase (MAO) inhibitors. It is chemically related to another antidepressant, trazodone (Desyrel) and shares its actions. The FDA approved nefazodone in December 1994.



PREPARATIONS: Tablets: 50, 100, 150, 200, and 250 mg.

STORAGE: Tablets of nefazodone should be kept at room temperature, below 40 C (104 F).

PRESCRIBED FOR: Nefazodone is used for the treatment of depression.

Medically Reviewed by a Doctor on 9/12/2014

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