PREPARATIONS: Tablet: 60 and 120 mg.
STORAGE: Nateglinide should be stored at room temperature, 15 C to 30 C (59 F to 86 F), in an air-tight container.
DOSING: The recommended dose of nateglinide alone or in combination with metformin or thiazolidinediones is 120 mg three times daily with meals. The 60 mg dose is used for patients who are close to their goal HbA1c when treatment is started. Nateglinide should be taken 30 minutes or less before a meal but should not be taken if a meal is skipped.
DRUG INTERACTIONS: Starting or stopping the following drugs may increase the response to nateglinide and may require the dose of nateglinide to be lowered: nonsteroidal anti-inflammatory agents (NSAIDs) like ibuprofen (Motrin, etc.), aspirin and aspirin-like compounds, monoamine oxidase inhibitors like phenelzine (Nardil), and beta-blocking drugs like propranolol (Inderal). Starting or stopping the following drugs may decrease the response to nateglinide and may require the dose of nateglinide to be increased: thiazide diuretics such as hydrochlorothiazide, steroids such as prednisone, thyroid hormone like levothyroxine, and drugs used in emergencies to regulate the heartbeat or restore breathing when airways are blocked. Examples of these latter drugs are epinephrine and albuterol (Ventolin).
PREGNANCY: No safety and efficacy studies have been conducted in pregnant women taking nateglinide. Nateglinide should not be used during pregnancy.
NURSING MOTHERS: No safety and efficacy studies have been conducted in pregnant women taking nateglinide. Since many drugs are excreted in breast milk, the manufacturer recommends that nateglinide not be administered to nursing mothers.
Medically reviewed by Eni Williams, PharmD
REFERENCE: FDA Prescribing Information
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