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- Type 2 Diabetes: Test Your Medical IQ
- What is nateglinide, and how does it work (mechanism of action)?
- What brand names are available for nateglinide?
- Do I need a prescription for nateglinide?
- What are the side effects of nateglinide?
- What is the dosage for nateglinide?
- Which drugs or supplements interact with nateglinide?
- Is nateglinide safe to take if I'm pregnant or breastfeeding?
- What else should I know about nateglinide?
What is the dosage for nateglinide?
The recommended dose of nateglinide alone or in combination with metformin or thiazolidinediones is 120 mg three times daily with meals. The 60 mg dose is used for patients who are close to their goal HbA1c when treatment is started. Nateglinide should be taken 30 minutes or less before a meal but should not be taken if a meal is skipped.
Which drugs or supplements interact with nateglinide?
Starting or stopping the following drugs may increase the response to nateglinide and may require the dose of nateglinide to be lowered: nonsteroidal anti-inflammatory agents (NSAIDs) like ibuprofen (Motrin, etc.), aspirin and aspirin-like compounds, monoamine oxidase inhibitors like phenelzine (Nardil), and beta-blocking drugs like propranolol (Inderal). Starting or stopping the following drugs may decrease the response to nateglinide and may require the dose of nateglinide to be increased: thiazide diuretics such as hydrochlorothiazide, steroids such as prednisone, thyroid hormone like levothyroxine, and drugs used in emergencies to regulate the heartbeat or restore breathing when airways are blocked. Examples of these latter drugs are epinephrine and albuterol (Ventolin).
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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