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Nasal Allergy Medications (cont.)

What are common side effects of antihistamines?

Since the first generation antihistamines can penetrate the brain tissue, they generally cause more side effects than the second generation drugs, which usually cannot enter the central nervous system. Drowsiness is the most noticeable side effect, but this is sometimes desirable. For example, it may be useful when nighttime symptoms prevent restful sleep. During the day, however, this effect can cause problems.

Allergy Alert

Be cautious about driving a car or operating a machine when using OTC antihistamines. Do not take any tranquilizers or drink alcohol along with these drugs. The combination may promote more drowsiness. Also, check with your doctor before taking an antihistamine if you have glaucoma or thyroid, heart, or prostate problems.

The first generation antihistamines may also cause troublesome anticholinergic effects such as heart palpitations, difficulty urinating, constipation, dry mouth, and nervousness. These side effects usually occur when the medication is taken at higher than recommended doses.

The second generation of antihistamines currently on the market has few, if any, significant side effects at the recommended doses.

Allergy Assist

Antihistamines may be used for nasal symptoms in patients with asthma. It was previously thought that these drugs would dry up the airways in the patient's bronchial tubes and aggravate the asthma. However, there is no good evidence supporting this notion. Additionally, as you will learn, improving nasal symptoms may benefit patients with asthma.


Next: What are decongestants? »

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