Narcotic Analgesics (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Severe side effects of narcotic analgesics are:

What drugs interact with narcotic analgesics?

Narcotic analgesics should not be used with the following monoamine oxidase inhibitors or MAOIs because of severe reactions that can be fatal.

Therefore, the discontinuation and initiation of narcotic analgesics and MAO inhibitors should be separated by at least 14 days.

Narcotic analgesics should be used with caution with central nervous system depressant medications such as alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), zolpidem (Ambien), zaleplon (Sonata) and alcohol because of increased risks of respiratory depression, low blood pressure, sedation, and in severe cases, coma and death.

Medically Reviewed by a Doctor on 2/3/2015

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