narcotic analgesic/aspirin/caffeine - oral (cont.)
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: acetazolamide, adenosine, antacids, anticholinergic medications (e.g., scopolamine), beta agonists (e.g., albuterol), certain antibiotics (e.g., penicillin, sulfonamides such as sulfamethoxazole, macrolide antibiotics such as erythromycin), certain anti-seizure medications (e.g., phenytoin, valproic acid), certain drugs used to treat gout (e.g., uricosuric drugs such as probenecid, sulfinpyrazone), cimetidine, corticosteroids (e.g., prednisone), disulfiram, drugs that may affect hearing (e.g., vancomycin), lithium, MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine), 6-mercaptopurine, methotrexate, mifepristone, naltrexone, other medications for pain (e.g., pentazocine, nalbuphine, morphine), pemetrexed, vemurafenib, zidovudine.This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also affect breathing or cause drowsiness. Therefore, tell your doctor or pharmacist if you are taking other products such as alcohol, medicine for sleep or anxiety (such as alprazolam, diazepam, meprobamate, zolpidem), muscle relaxants, and other narcotic pain relievers (such as morphine).Check the labels on all your medicines (e.g., cough-and-cold products, other headache medications) because they may contain aspirin, caffeine, or drowsiness-causing ingredients. Also keep in mind that certain beverages (e.g., coffee, colas, tea) contain caffeine. Ask your pharmacist about using those products safely.Also, check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as ibuprofen, ketorolac, naproxen, aspirin) that may increase your risk for side effects if taken together with this medication. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.This medication may interfere with certain medical/laboratory tests (including fasting blood glucose, cholesterol levels, prothrombin time, urine 5-HIAA levels, amylase and lipase levels, certain urine glucose tests, dipyridamole-thallium imaging tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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