butalbital/acetaminophen/caffeine (Alagesic LQ, Capacet, Dolgic Plus, Esgic, Fioricet, and Others) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: Butalbital/acetaminophen/caffeine should not be used with MAOI (monoamine oxidase inhibitors) like phenelzine (Nardil) and selegiline (Emsam) because they can significantly increase central nervous system effects of butalbital and increased blood levels of caffeine.

Butalbital can increase the effects of narcotic pain killers, alcohol, sedative or hypnotic medications, and other medications that depress the central nervous system. Loss of consciousness, troubled breathing, lowered heart rate, coma, and in severe cases death can occur.

PREGNANCY: There are no adequate studies done on butalbital/acetaminophen/caffeine to determine its safe and effective use in pregnant women.

NURSING MOTHERS: Butalbital/acetaminophen/caffeine enters breast milk in small amounts; therefore, it is best to be cautious before using it in nursing mothers.

SIDE EFFECTS: Side effects of butalbital/acetaminophen/caffeine are lightheadedness, dizziness, shortness of breath, nausea, dry mouth, increase heart rate, and tremors.

Butalbital/acetaminophen/caffeine has a boxed warning of liver toxicity if used in excessive amounts for prolonged periods. Acetaminophen dosage should not exceed 4000 mg per day to avoid acute liver injury. Butalbital is habit forming and may be abused.

Tolerance, dependence, and physical dependence may occur after prolonged periods of use of barbiturates (butalbital).

This product is contraindicated in patients who have hypersensitivity to any of its compounds and in patients with porphyria.


MedlinePlus. Acetaminophen, Butalbital, and Caffeine.

Medscape. butalbital/acetaminophen/caffeine (Rx).

Medically Reviewed by a Doctor on 6/23/2014

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.

Back to Medications Index