butalbital/acetaminophen/caffeine (Alagesic LQ, Capacet, Dolgic Plus, Esgic, Fioricet, and Others)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

A Guide to Migraine Headaches

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Alagesic LQ is available in tropical fruit punch flavor, oral solution form. It contains 50 mg butalbital, 325 mg acetaminophen, and 40 mg caffeine per 15 ml of solution. It contains 7.368% alcohol. It is available in 16 fluid ounce containers.
  • Capacet, Esgic, Fioricet, Margesic, Orbivan, and generic capsules contain butalbital/ acetaminophen/caffeine in 50 mg/325 mg/40 mg strengths.
  • Esgic, Fioricet, Nonbac, Repan and generic tablets are available in 50 mg/325 mg/40 mg strengths.
  • Esgic-Plus, Zebutal, and generic tablets are available in 50 mg/500 mg/40 mg strengths.
  • Dolgic Plus tablets are available in 50 mg/750 mg/40 mg strength.
  • Generic tablets are also available in reformulated strengths, which contain 300 mg acetaminophen.

STORAGE: Alagesic LQ is stored at room temperature between 20 C to 25 C (68 F to 77 F). Butalbital / acetaminophen / caffeine containing tablets and capsules should be stored between 15 C to to30 to C (59 F to to 86 F).

PRESCRIBED FOR: Butalbital/acetaminophen/caffeine is used for complex of tension or muscle contraction headaches.

DOSING:

Adults and children of 12 years of age and older

  • 50/325/40 mg tablets or capsules: Take 1 to 2 tablets by mouth every 4 hours. Maximum of 6 doses per day. Not to exceed 4000 mg of acetaminophen per day to avoid liver injury.
  • Dolgic Plus (50/750/40 mg): Take 1 tablet by mouth every 4 hours. Maximum of 5 tablets per day.
  • Alagesic LQ: Take 1 to 2 tablespoons (15-30 ml) by mouth every 4 hours. Maximum daily dose of 6 tablespoons (180 ml) per day.
  • Safe and effective use of butalbital/acetaminophen/caffeine is not established in children under 12 years of age.

DRUG INTERACTIONS: Butalbital/acetaminophen/caffeine should not be used with MAOI (monoamine oxidase inhibitors) like phenelzine (Nardil) and selegiline (Emsam) because they can significantly increase central nervous system effects of butalbital and increased blood levels of caffeine.

Quick GuideMigraine or Headache? Migraine Symptoms, Triggers, Treatment

Migraine or Headache? Migraine Symptoms, Triggers, Treatment
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