Medications and Drugs
Medical Author: Omudhome Ogbru, Pharm.D.
Medical Editor: Jay Marks, M.D.
GENERIC NAME: naproxen
BRAND NAME: Anaprox, Naprelan, Naprosyn, Aleve
DRUG CLASS AND MECHANISM: Naproxen belongs to a class of drugs called
nonsteroidal antiinflammatory drugs (NSAIDs). Other members of this class
include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and
several others. These drugs are used for the management of mild to moderate
pain, fever, and inflammation. They work by reducing the levels of
prostaglandins, chemicals that are responsible for pain, fever, and inflammation.
Naproxen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting
in lower concentrations of prostaglandins. As a consequence, inflammation, pain
and fever are reduced. Naproxen was approved by the FDA in December 1991.
PRESCRIPTION: Yes; (Aleve, no)
GENERIC AVAILABLE: Yes
PREPARATIONS:
- Anaprox (tablets): 275 and 550 mg;
- Naprosyn (tablets): 250, 375, and 500 mg;
- Naprosyn suspension: 125 mg/5ml;
- EC-Naprosyn: 375 mg,
- Aleve: 220 mg;
- Naprelan (controlled-release tablets): 375 and 500mg.
STORAGE: Naproxen should be stored at room temperature: 15-30 C
(59-86 F).
PRESCRIBED FOR: Naproxen is used for the treatment of mild to moderate
pain, inflammation, and fever.
DOSING: The usual adult dose is 250-500 mg twice daily using regular
naproxen tablets. The usual dose for Naprelan controlled release tablets is 750
to 1000 mg given once daily. For EC-Naprosyn, the usual dose is 375-500 mg twice
daily. Naproxen should be given with food to reduce upset stomach.
DRUG INTERACTIONS: Naproxen is associated with several suspected or
probable interactions that affect the action of other drugs. The following
examples are the most common suspected interactions.
Naproxen may increase the blood levels of
lithium (Eskalith) by reducing the
excretion of lithium by the kidneys. Increased levels of lithium may lead to
lithium toxicity.
Naproxen may reduce the blood pressure lowering effects of
blood pressure
medications. This may occur because prostaglandins play a role in the regulation
of blood pressure.
When naproxen is used in combination with methotrexate or aminoglycosides (for example, gentamicin) the
blood levels of the methotrexate or aminoglycoside may increase, presumably because
the elimination from the body is reduced. This may lead to more methotrexate or
aminoglycoside-related side effects.
Individuals taking oral blood thinners or anticoagulants [for example, warfarin,
(Coumadin)]
should avoid naproxen because naproxen also thins the blood, and excessive blood
thinning may lead to bleeding.
PREGNANCY: There are no adequate studies of naproxen in pregnant
women. Therefore, naproxen is not recommended during
pregnancy.
NURSING MOTHERS: A small amount of naproxen is excreted in breast
milk. Because the concentration in breast milk is low,
breastfeeding while
taking naproxen probably is not harmful to the infant.
SIDE EFFECTS: The most common side effects from naproxen are rash,
ringing in the ears,
headaches, dizziness, drowsiness, abdominal pain, nausea,
diarrhea, constipation, heartburn, fluid retention and shortness of breath.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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