naloxone - hydrochloride injection (Narcan, Evzio) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Postoperative opioid depression: 0.005 to 0.01 mg IV every 2 to 3 minutes as needed.

DRUG INTERACTIONS: Large doses of Naloxone are required when used together with buprenorphine since buprenorphine binds and dissociates slowly from mu receptors. Large doses of Naloxone may cause respiratory distress.

PREGNANCY: There are no adequate studies done on Naloxone to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether Naloxone enters breast milk; therefore, it is best to be cautious before using it in women who are breastfeeding.

SIDE EFFECTS: Side effects of Naloxone are increase or decrease in blood pressure, abnormal heart rate and rhythm, troubled breathing, cardiac arrest, fluid retention in lungs, and diarrhea.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 6/13/2014

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