naloxone - hydrochloride injection (Narcan, Evzio) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PREGNANCY AND BREASTFEEDING SAFETY: There are no adequate studies done on Naloxone to determine safe and effective use in pregnant women. It is not known whether Naloxone enters breast milk; therefore, it is best to be cautious before using it in women who are breastfeeding.

STORAGE: Store Naloxone injections at room temperature 20 C to 25 C (68 F to 77 F).

DOSING:

Adults

  • Opioid overdose: 0.4 to 2 mg intravenous (IV), intramuscular (IM), or subcutaneous injection every 2 to 3 minutes as needed; however, after10 mg administered, it is recommended that its use be reassessed as the symptoms may not be due to opiate activity.
  • Reversal of opiate activity: 0.1 to 0.2 mg IV, IM, or subcutaneous injection every 2 to 3 minutes as needed.

Children (5 years or older OR 20 kg or less):

  • Opioid overdose: Initially 0.01 mg/kg IV; may increase to 0.1 mg/kg if necessary.
  • Postoperative opioid depression: 0.005 to 0.01 mg IV every 2 to 3 minutes as needed.

DRUG CLASS AND MECHANISM:

  • Naloxone is a man-made opioid antagonist, which means that it blocks the action of opioid medications such as morphine and related drugs.
  • Naloxone works by binding to mu-receptors in the brain that opioids use to produce their effect on pain and other symptoms.
  • By binding to mu receptors, naloxone reverses opioid activity in the body.

Medically reviewed by Eni Williams, PharmD

REFERENCE: FDA Prescribing Information.


Medically Reviewed by a Doctor on 1/22/2016


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