naloxone - hydrochloride injection (Narcan, Evzio) (cont.)

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  • Opioid overdose: 0.4 to 2 mg intravenous (IV), intramuscular (IM), or subcutaneous injection every 2 to 3 minutes as needed; however, after10 mg administered, it is recommended that its use be reassessed as the symptoms may not be due to opiate activity.
  • Reversal of opiate activity: 0.1 to 0.2 mg IV, IM, or subcutaneous injection every 2 to 3 minutes as needed.

Children (5 years or older OR 20 kg or less):

  • Opioid overdose: Initially 0.01 mg/kg IV; may increase to 0.1 mg/kg if necessary.

Postoperative opioid depression: 0.005 to 0.01 mg IV every 2 to 3 minutes as needed.

DRUG INTERACTIONS: Large doses of Naloxone are required when used together with buprenorphine since buprenorphine binds and dissociates slowly from mu receptors. Large doses of Naloxone may cause respiratory distress.

PREGNANCY: There are no adequate studies done on Naloxone to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether Naloxone enters breast milk; therefore, it is best to be cautious before using it in women who are breastfeeding.

SIDE EFFECTS: Side effects of Naloxone are increase or decrease in blood pressure, abnormal heart rate and rhythm, troubled breathing, cardiac arrest, fluid retention in lungs, and diarrhea.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 6/13/2014

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