naloxone - hydrochloride injection (Narcan, Evzio)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Prescription Drug Abuse Statistics

GENERIC NAME: naloxone hydrochloride

BRAND NAME: Narcan, Evzio

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

USES: Naloxone is used for partial or complete opioid competitive binding of mu-receptors to reverse respiratory depression and to treat opioid overdose symptoms. It is also used to increase blood pressure in people with septic shock.

SIDE EFFECTS: Side effects of Naloxone are:

PREPARATIONS: Injection: 0.4 and 1 mg/ml; Auto Injector: 0.4 mg/0.4 ml

DRUG INTERACTIONS: Large doses of Naloxone are required when used together with buprenorphine since buprenorphine binds and dissociates slowly from mu receptors. Large doses of Naloxone may cause respiratory distress.

Medically Reviewed by a Doctor on 1/22/2016

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