naloxone - hydrochloride injection (Narcan, Evzio)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is naloxone-injection, and how does it work (mechanism of action)?

  • Naloxone is a man-made opioid antagonist, which means that it blocks the action of opioid medications such as morphine and related drugs.
  • Naloxone works by binding to mu-receptors in the brain that opioids use to produce their effect on pain and other symptoms.
  • By binding to mu receptors, naloxone reverses opioid activity in the body.

What brand names are available for naloxone-injection?

Narcan, Evzio

Is naloxone-injection available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for naloxone-injection?

Yes

What are the uses for naloxone-injection?

Naloxone is used for partial or complete opioid competitive binding of mu-receptors to reverse respiratory depression and to treat opioid overdose symptoms. It is also used to increase blood pressure in people with septic shock.

What are the side effects of naloxone-injection?

Side effects of Naloxone are:

Medically Reviewed by a Doctor on 1/22/2016

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