Nalbuphine should not be used with MAO inhibitors like phenelzine (Nardil), selegiline (Zelapar, Emsam, Eldepryl), and isocarboxazid (Marplan) as well as linezolid (Zyvox) antibiotic because they can increase nalbuphine toxicity, causing decreased blood pressure, fever, sleepiness, and in severe cases, death. Nalbuphine administration must be separated by 14 days from MAOI inhibitors and linezolid (Zyvox).
PREGNANCY: There are no adequate studies of nalbuphine to determine safe and effective use in pregnant women. Nalbuphine should be used only if clearly needed and the benefit outweighs the risk to fetus. It is used during labor and delivery.
NURSING MOTHERS: Nalbuphine may enter breast milk in trace amount; therefore, it should be used with caution in mothers who are nursing.
SIDE EFFECTS: Side effects of Nalbuphine are sedation, dizziness, nausea, vomiting, dry mouth, headache, and low heart rate. Like other narcotics nalbuphine can cause respiratory depression (decreased rate or depth of breathing).
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