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There has been some concern that glucosamine products might cause allergic reactions in people who are sensitive to shellfish. Glucosamine is produced from the shells of shrimp, lobster, and crabs. But allergic reactions in people with shellfish allergy are caused by the meat of shellfish, not the shell. There are no reports of allergic reactions to glucosamine in people who are allergic to shellfish. On the positive side, there is also some information that people with shellfish allergy can safely take glucosamine products.
There has also been a concern that glucosamine might increase the amount of insulin in the body. Too much insulin might lead to high blood pressure and high levels of cholesterol and other blood fats called triglycerides. While animal research seems to confirm that glucosamine can increase cholesterol, researchers haven't found this effect in people. In fact, research findings to date show that glucosamine does not seem to increase blood pressure or raise cholesterol levels in people over age 45 who take glucosamine sulfate for up to 3 years.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of N-acetyl glucosamine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Asthma: Researchers aren't sure why, but glucosamine might make asthma worse in some people. If you have asthma, use caution when trying glucosamine.
Diabetes: Some early research suggested that glucosamine might raise blood sugar in people with diabetes. However, more reliable research indicates that glucosamine does not seem to significantly affect blood sugar control in people with type 2 diabetes. As long as you routinely monitor your blood sugar, you can probably take glucosamine safely.
Surgery: N-acetyl glucosamine might affect blood sugar levels and might interfere with blood sugar control during and after surgery. Stop taking N-acetyl glucosamine at least 2 weeks before a scheduled surgery.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.