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The Cleveland Clinic

Diagnosing Heart Disease: Myocardial Biopsy

Myocardial biopsy, or cardiac biopsy, is procedure that involves using a bioptome (a small catheter with a grasping device on the end) to obtain a small piece of heart muscle tissue to send to a laboratory for analysis.

Why Do I Need a Myocardial Biopsy?

Your doctor uses myocardial biopsy to:

  • Evaluate or confirm the presence of rejection after heart transplant.
  • Diagnose myocarditis (inflammation of the heart muscle) or the cause of cardiomyopathy (heart muscle disease).

How Should I Prepare for the Biopsy?

  • You can wear whatever you like to the hospital, but it is a good idea to leave valuables, such as jewelry, at home. You will wear a hospital gown during the procedure.
  • Your doctor or nurse will give you specific instructions about what you can and cannot eat or drink before the procedure.
  • Ask your doctor what medications should be taken on the day of your test.
  • If you are diabetic, ask your doctor how to adjust your medications the day of your test.
  • Tell your doctor and/or nurses if you are allergic to anything.
  • Arrange for someone to drive you home after the test.

What Can I Expect During the Procedure?

  • After you change into a hospital gown, a nurse will start an intravenous (IV) line in your arm so that medications and fluids can be administered during the procedure.
  • You will lie on a special table. If you look above, you will see a large camera and several TV monitors
  • You will be awake and conscious during the entire procedure. The doctor will use medication to numb the area of your neck. A plastic introducer sheath (a short, hollow tube through which the catheter is placed) is inserted into a blood vessel. A bioptome will be inserted through the sheath and threaded to your right ventricle. An X-ray camera may be used to position the bioptome properly.
  • After the bioptome has obtained samples of your heart muscle, (the sample is about the size of the top of a pin), the catheter is removed and firm pressure is held over the area to stop bleeding.
  • The procedure takes about 30 to 60 minutes.

Reviewed by the doctors at The Cleveland Clinic Taussig Cancer Center.

Edited by Charlotte E. Grayson, MD, WebMD, June 2004.

Portions of this page copyright © The Cleveland Clinic 2000-2004


Last Editorial Review: 1/31/2005 10:50:22 AM




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Suggested Reading by Our Doctors
MedicineNet Doctors
  • Heart Transplant - Learn about heart transplant, the replacement of a person's heart with a healthy donor's heart. Complications include health of the patient, donor availability, and organ rejection.
  • Myocarditis - Learn about myocarditis, an inflammation of the heart muscle caused by infections, viruses, or immune diseases such as sarcoidosis, lupus, pregnancy, and more.
  • Cardiomyopathy (Dilated) - Dilated cardiomyopathy (DCM) can be inherited,but it is primarily caused by:Severe coronary artery disease, Alcoholism, thyroid disease, diabetes, viral infections of the heart, heart valvue abnormalities, toxic drugs

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Myocardial Biopsy

What is myocarditis?

Myocarditis is inflammation of heart muscle.

What causes myocarditis?

Myocarditis can be caused by a variety of infections and conditions such as viruses, sarcoidosis, and immune diseases (such as systemic lupus, etc.), pregnancy, and others. The most common cause of myocarditis is infection of the heart muscle by a virus. The virus invades the heart muscle to cause local inflammation. After the initial infection subsides, the body's immune system continues to inflict inflammatory damage to the heart muscle. This immune response actually prolongs the myocarditis.

What are symptoms of myocarditis?

Myocarditis can be mild and cause virtually no noticeable symptoms. The most frequent symptom of myocarditis is pain in the chest. When myocarditis is more serious, it leads to weakening of the heart muscle. Myocarditis can then cause heart failure (with symptoms of shortness of breath, fatig...

Read the Myocarditis article »










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