mycophenolate mofetil (CellCept)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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It may also cause:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Powder for injection: 500 mg
  • Capsules: 250 mg
  • Immediate-release tablets: 500 mg
  • Delayed-release tablets: 180 and 360 mg
  • Oral suspension: 200 mg/ml

STORAGE:

  • Capsules and tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
  • Oral suspension may be stored at room temperate between 15 C and 30 C (59 F and 86 F) for up to 60 days.
  • Oral suspension also may be stored in the refrigerator between 2 C and 8 C (36 F and 46 F), but it should not be frozen.

DOSING: Mycophenolate mofetil should be given to patients as soon as possible following organ transplantation. Mycophenolate mofetil is recommended to be administered on an empty stomach, except in stable renal transplant patients in whom it can be administered with food if necessary.

Kidney transplantation

  • Adults: The recommended dose is 1 g administered orally or intravenously (over no less than 2 hours) twice a day.
  • Pediatrics (3 months to 18 years of age): The recommended dose of the oral suspension is 600 mg/m2 administered twice daily (maximum daily dose of 2 g/10 ml). Patients with a body surface area of 1.25 m2 to 1.5 m2 may be administered capsules at a dose of 750 mg twice daily. Patients with a body surface area >1.5 m2 may be dosed with capsules or tablets at a dose of 1 g twice daily.

Heart transplantation

  • Adults: The recommended dose is 1.5 g twice daily administered intravenously over no less than 2 hours or 1.5 g orally twice daily.

Liver Transplantation

  • Adults: The recommended dose is 1 g twice daily administered intravenously over no less than 2 hours or 1.5 g orally twice daily.
  • Geriatrics (elderly patients): The recommended oral dose is 1 g twice daily for kidney transplant patients, 1.5 g twice daily for heart transplant patients, and 1 g twice daily administered intravenously or 1.5 g twice daily administered orally in liver transplant patients.
Medically Reviewed by a Doctor on 6/2/2015

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