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- What is mycophenolate mofetil-oral, and how does it work (mechanism of action)?
- What brand names are available for mycophenolate mofetil-oral?
- Is mycophenolate mofetil-oral available as a generic drug?
- Do I need a prescription for mycophenolate mofetil-oral?
- What are the side effects of mycophenolate mofetil-oral?
- What is the dosage for mycophenolate mofetil-oral?
- Which drugs or supplements interact with mycophenolate mofetil-oral?
- Is mycophenolate mofetil-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about mycophenolate mofetil-oral?
What is mycophenolate mofetil-oral, and how does it work (mechanism of action)?
Mycophenolic acid is an immunosuppressive drug. Mycophenolate mofetil is a prodrug (inactive form) of mycophenolic acid (MPA). Following oral administration, mycophenolate mofetil is rapidly absorbed and hydrolyzed (converted) to MPA. MPA is the active metabolite which has pharmacological activity.
MPA is a strong, reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). IMPDH plays a critical role in the production of DNA. T and B lymphocytes (immune cells) are heavily dependent on the activity of IMPDH to make DNA to proliferate, whereas other cells can use alternative pathways. In patients who have received transplanted organs, the recipient's immune system attacks the transplanted organ because the body perceives it as foreign or harmful. MPA decreases the activity of the immune system by inhibiting the proliferation of immune cells that attack the transplanted organ. Mycophenolate is used with other medications that also inhibit the rejection of transplanted organs such as cyclosporine (Sandimmune, Gengraf, Neoral) and corticosteroids.
Mycophenolate mofetil was approved by the U.S. FDA on May 3, 1995.
What brand names are available for mycophenolate mofetil-oral?
Is mycophenolate mofetil-oral available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for mycophenolate mofetil-oral?
What are the side effects of mycophenolate mofetil-oral?
Common side effects include:
- pain in the stomach area,
- high blood pressure, and
- swelling of the lower legs, ankles, or feet.
It may also cause:
- blood infection,
- sore throat,
- low white and red blood cell count, and
- low blood platelets (thrombocytopenia).
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